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Updated: Aug 16, 2026
11:55
Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Activated T-cell in autoimmune haemolytic anaemia
British Journal of Haematology
|July 1, 1977
Summary
High levels of T-lymphocytes, identified as rosetting cells, were found in patients with active autoimmune haemolytic anaemia. These levels correlated directly with disease activity over a two-year observation period.
Area of Science:
- Immunology
- Hematology
Background:
- Autoimmune haemolytic anaemia (AIHA) is characterized by the immune system attacking red blood cells.
- The specific cellular mechanisms driving AIHA activity require further elucidation.
Purpose of the Study:
- To investigate the presence and significance of rosetting cells in patients with active autoimmune haemolytic anaemia.
- To determine the relationship between rosetting cell levels and disease activity.
Main Methods:
- Analysis of peripheral blood samples from patients with clinically active AIHA.
- Quantification of homologous and autologous rosetting cells.
- Longitudinal observation of rosetting cell levels over two years.
Main Results:
- High levels of homologous and autologous rosetting cells (9-78%) were detected in 12 out of 14 AIHA patients.
- In 10 patients, rosetting cell levels directly correlated with disease activity.
- The identified rosetting cells were characterized as T-lymphocytes.
Conclusions:
- T-lymphocytes forming rosettes are significantly elevated in active AIHA.
- Rosetting cell levels serve as a potential biomarker for monitoring AIHA disease activity.
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