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Updated: Dec 7, 2025

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
Published on: November 1, 2024
NMR resonance assignment and dynamics of profilin from Heimdallarchaeota
Syed Razaul Haq1, Sabeen Survery1, Fredrik Hurtig1
1Department of Molecular BioScience, Wenner-Gren Institute, Stockholm University, Svante Arrhenius v. 20C, 10691, Stockholm, Sweden.
Abstract:
The origin of the eukaryotic cell is an unsettled scientific question. The Asgard superphylum has emerged as a compelling target for studying eukaryogenesis due to the previously unseen diversity of eukaryotic signature proteins. However, our knowledge about these proteins is still relegated to metagenomic data and very little is known about their structural properties. Additionally, it is still unclear if these proteins are functionally homologous to their eukaryotic counterparts. Here, we expressed, purified and structurally characterized profilin from Heimdallarchaeota in the Asgard superphylum. The structural analysis shows that while this profilin possesses similar secondary structural elements as eukaryotic profilin, it contains additional secondary structural elements that could be critical for its function and an indication of divergent evolution.
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