Glycosaminoglycan composition of tight skin and control mouse skins

Tight skin (TSK) mouse skin has previously been shown to contain increased amounts of collagen and glycosaminoglycans (GAG). We now report on the GAG composition of TSK mouse skin. Using an electrophoretic and an enzymatic HPLC method, skin from 99 TSK and control mice (newborn, 1 month-old, and 6 months-old) were analyzed for GAG composition. There was no significant difference between TSK and control GAG.