Related Experiment Video
Updated: Dec 7, 2025
03:26
Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
Published on: March 8, 2024
3.3K
Functional pain disorders - more than nociplastic pain
Stoyan Popkirov1, Elena K Enax-Krumova2, Tina Mainka3,4
1Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany.
Neurorehabilitation
|September 28, 2020
Summary
Nociplastic pain, a new pain category, involves altered neural processing. Conditions like chronic back pain benefit from biopsychosocial, multimodal treatments focusing beyond just pain relief.
Area of Science:
- Neurology
- Pain Medicine
- Neuroscience
Background:
- Nociplastic pain is a third pain descriptor, distinct from nociceptive and neuropathic pain.
- It involves altered neural processing, hyperalgesia, allodynia, and interactions with biological/psychobehavioral factors.
- Functional pain disorders are reframed as biopsychosocial conditions requiring multimodal treatment.
Purpose of the Study:
- To review the understanding of nociplastic pain.
- To discuss functional pain disorders relevant to neurological practice.
Main Methods:
- Narrative literature review.
Main Results:
- Chronic back pain, fibromyalgia, and CRPS are best understood through a biopsychosocial lens.
- Treatment should address accompanying symptoms (sleep, mood) alongside pain.
- Analgesic pharmacotherapy is less effective alone; multidisciplinary approaches are key.
Conclusions:
- Nociplastic pain and functional pain disorders require a comprehensive, biopsychosocial approach.
- Multimodal treatment strategies are crucial for managing these complex pain conditions.
Related Concept Videos
01:25Analgesia and Pain Management
1.3K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.3K
01:44Nociception
32.6K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
32.6K
01:20Pain
1.1K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.1K
01:24Chronic Pancreatitis I: Introduction
539
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
539
01:15Opioid Analgesics: Synthetic and Semisynthetic Opioids
747
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
747
01:17Chronic Bowel Disorders: Introduction
664
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
664