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Published on: August 12, 2021
COVID-19: Significance of antibodies
Sara Assadiasl1, Yousef Fatahi2,3, Mahdi Zavvar4
1Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:
The newly emerged severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has recently caused pandemic Coronavirus Disease-2019 (COVID-19). Considering the serious medical, economic and social consequences of this pandemic and the lack of definite medication and vaccine it is necessary to describe natural immune responses to the SARS-CoV-2 in order to exploit them for treating the patients and monitoring the general population. Moreover, detecting the most immunogenic antigens of the virus is fundamental for designing effective vaccines. Antibodies being valuable for diagnostic therapeutic and protective purposes are suitable to be addressed in this context. Herein, we have summarized the findings of serological investigations and the outcomes of neutralizing antibodies administration in COVID-19 patients.
Insights
This study reviews immune responses to SARS-CoV-2, focusing on antibodies for COVID-19 diagnosis, treatment, and vaccine development. It summarizes serological findings and the impact of neutralizing antibodies in patients.
Area of Science:
- Immunology
- Virology
- Epidemiology
Background:
- The emergence of SARS-CoV-2 causing the COVID-19 pandemic necessitates understanding natural immune responses.
- Lack of definitive treatments and vaccines highlights the need to leverage host immunity.
- Serological investigations are crucial for diagnostics, therapeutics, and vaccine design.
Purpose of the Study:
- To summarize serological findings related to SARS-CoV-2 infection.
- To review the outcomes of neutralizing antibody administration in COVID-19 patients.
- To identify key viral antigens for effective vaccine development.
Main Methods:
- Review of serological investigation data.
- Analysis of outcomes from neutralizing antibody administration.
- Literature synthesis on immune responses to SARS-CoV-2.
Main Results:
- Summarized findings from serological studies on COVID-19 patients.
- Documented outcomes of using neutralizing antibodies for treatment.
- Identified critical aspects of the immune response to SARS-CoV-2.
Conclusions:
- Understanding SARS-CoV-2 immune responses is vital for managing the pandemic.
- Antibodies play a significant role in diagnosis, therapy, and prevention.
- Further research into immunogenic antigens will accelerate vaccine development.
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