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Sleep Dysfunction in Huntington's Disease: Perspectives from Patients.
Will K Tanigaki1, Maria A Rossetti2, Natalia P Rocha3
1McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
Journal of Huntington'S Disease
|September 28, 2020
Summary
Sleep disturbances are common in Huntington's disease (HD) patients and their caregivers, worsening cognitive and mood symptoms. Routine sleep assessments are crucial for managing this nonmotor symptom in HD.
Area of Science:
- Neurology
- Sleep Medicine
- Neurodegenerative Diseases
Background:
- Sleep disorders are frequently overlooked in Huntington's disease (HD) clinical evaluations.
- Sleep disturbances can significantly worsen cognitive and mood impairments in HD patients.
- These sleep issues negatively impact the quality of life for both patients and their families.
Purpose of the Study:
- To investigate sleep quality in Huntington's disease (HD) patients.
- To examine the association between sleep quality and clinical symptoms in HD.
- To explore sleep quality in caregivers of HD patients.
Main Methods:
- Utilized self-reported questionnaires for sleep quality, cognitive function, and mood symptoms.
- Included 29 HD patients and 22 caregivers in the study.
- Employed Spearman correlation analyses to assess relationships between variables.
Main Results:
- Common complaints included nighttime awakenings and increased sleep latency.
- A majority of HD patients (59%) and caregivers (55%) were identified as poor sleepers.
- Worse sleep quality correlated with increased anxiety, depression, and decreased self-perceived cognitive function in both groups.
Conclusions:
- Enhanced awareness and understanding of sleep dysfunction in HD are essential.
- Integrating regular sleep assessments into routine HD patient evaluations is recommended.
- Addressing sleep problems can alleviate a significant nonmotor symptom in Huntington's disease.
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