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Resting TcPO2 levels decrease during liner wear in persons with a transtibial amputation
Martin C Berli1, Michèle Jundt-Ecker1, Margrit R Meier2
1Department of Orthopaedic Surgery, Balgrist University Hospital, Zurich, Switzerland.
Plos One
|September 28, 2020
Summary
Silicone liners significantly reduce transcutaneous oxygen pressure (TcPO2) in transtibial amputees, potentially contributing to residual limb pain. Further research is needed to explore exercise-induced effects.
Area of Science:
- Biomedical Engineering
- Prosthetics and Orthotics
- Clinical Medicine
Background:
- A significant number of patients experience transtibial residual limb pain without a clear somatic origin.
- Silicone liners may reduce blood flow through tissue compression, potentially causing this pain.
Purpose of the Study:
- To investigate the immediate effect of silicone liners on transcutaneous oxygen pressure (TcPO2) in transtibial amputees.
Main Methods:
- Twenty participants with unilateral transtibial amputation and unexplained residual limb pain were included.
- Resting TcPO2 was measured at the tibia end (TTE) and peroneal compartment (SPC) with and without a liner.
- Statistical analysis compared TcPO2 levels under both conditions.
Main Results:
- Liner wear significantly decreased resting TcPO2 levels at both sensor sites (TTE: p < 0.001; SPC: p = 0.002).
- No significant associations were found between TcPO2 levels and pain, smoking, age, or mobility.
- TcPO2 levels did not differ significantly over time or between sensor locations.
Conclusions:
- Wearing a silicone liner alone, without a prosthetic socket, significantly reduces resting TcPO2.
- Further studies are necessary to examine the impact of liner wear on exercise-induced TcPO2 levels.

