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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Related Experiment Video

Updated: Dec 7, 2025

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
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Resting TcPO2 levels decrease during liner wear in persons with a transtibial amputation.

Martin C Berli1, Michèle Jundt-Ecker1, Margrit R Meier2

  • 1Department of Orthopaedic Surgery, Balgrist University Hospital, Zurich, Switzerland.

Plos One
|September 28, 2020
PubMed
Summary
This summary is machine-generated.

Silicone liners significantly reduce transcutaneous oxygen pressure (TcPO2) in transtibial amputees, potentially contributing to residual limb pain. Further research is needed to explore exercise-induced effects.

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Area of Science:

  • Biomedical Engineering
  • Prosthetics and Orthotics
  • Clinical Medicine

Background:

  • A significant number of patients experience transtibial residual limb pain without a clear somatic origin.
  • Silicone liners may reduce blood flow through tissue compression, potentially causing this pain.

Purpose of the Study:

  • To investigate the immediate effect of silicone liners on transcutaneous oxygen pressure (TcPO2) in transtibial amputees.

Main Methods:

  • Twenty participants with unilateral transtibial amputation and unexplained residual limb pain were included.
  • Resting TcPO2 was measured at the tibia end (TTE) and peroneal compartment (SPC) with and without a liner.
  • Statistical analysis compared TcPO2 levels under both conditions.

Main Results:

  • Liner wear significantly decreased resting TcPO2 levels at both sensor sites (TTE: p < 0.001; SPC: p = 0.002).
  • No significant associations were found between TcPO2 levels and pain, smoking, age, or mobility.
  • TcPO2 levels did not differ significantly over time or between sensor locations.

Conclusions:

  • Wearing a silicone liner alone, without a prosthetic socket, significantly reduces resting TcPO2.
  • Further studies are necessary to examine the impact of liner wear on exercise-induced TcPO2 levels.