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Updated: Dec 7, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Cobalt(III)-Catalyzed Enantioselective Intermolecular Carboamination by C-H Functionalization
Kristers Ozols1, Shunsuke Onodera1,2, Łukasz Woźniak1
1Institute of Chemical Sciences and Engineering (ISIC), EPFL SB ISIC LCSA, BCH 4305, 1015, Lausanne, Switzerland.
Abstract:
High-valent cyclopentadienyl cobalt catalysis is a versatile tool for sustainable C-H bond functionalizations. To harness the full potential of this strategy, control of the stereoselectivity of these processes is necessary. Herein, we report highly enantioselective intermolecular carboaminations of alkenes through C-H activation of N-phenoxyamides catalyzed by CoIII -complexes equipped with chiral cyclopentadienyl (Cpx ) ligands. The method converts widely available acrylates as well as bicyclic olefins into attractive enantioenriched isotyrosine derivatives as well as elaborated amino-substituted bicyclic scaffolds under very mild conditions. The outlined reactivity is unique to the Cpx CoIII complexes and is complementary to the reactivity of 4d- and 5d- precious-metal catalysts.
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