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Allergic sensitization pattern of patients in Brazil
Carolina Sanchez Aranda1, Renata R Cocco1, Felipe F Pierotti1
1Universidade Federal de São Paulo, Departamento de Pediatria, São Paulo, SP, Brazil.
Jornal De Pediatria
|September 28, 2020
Summary
Allergic sensitization patterns in Brazilian children reveal dust mites are the most common allergen. Food allergies and atopic dermatitis increase the risk of severe allergic diseases, highlighting the need for targeted prevention strategies.
Area of Science:
- Immunology
- Allergology
- Pediatrics
Background:
- Allergic sensitization is crucial for allergy development and severity.
- Polysensitization correlates with persistent and severe allergic conditions.
- Understanding sensitization patterns aids in allergy management.
Purpose of the Study:
- To characterize allergic sensitization patterns in atopic Brazilian pediatric patients.
- To identify common allergens and risk factors for severe disease.
Main Methods:
- Nation-wide, transversal, multicenter study in Brazil.
- Serum allergen-specific IgE levels measured in 470 individuals.
- Quantification of specific components for IgE levels > 0.1 kUA/L.
Main Results:
- Mite sensitization was the most frequent allergen overall.
- High rates of sensitization to furry animals and grasses observed.
- Der p 1 and Der p 2 were the predominant sensitizing components.
- Food allergy, atopic dermatitis, and multimorbidity are risk factors for severe disease.
Conclusions:
- Dust mite sensitization is highly prevalent in this Brazilian pediatric cohort.
- Sensitization to furry animals is also significant.
- Identifying at-risk patients (food allergy, atopic dermatitis, multimorbidity) is key for managing severe allergic diseases.
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