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Updated: Dec 7, 2025

Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Ketogenic diet and Neuroinflammation.

Sookyong Koh¹, Nina Dupuis², Stéphane Auvin³

¹Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA.

Epilepsy Research

|September 28, 2020

Summary

The ketogenic diet (KD) effectively treats epilepsy by modulating immune responses. Emerging research suggests KD also offers neuroprotection and anti-inflammatory benefits for various neurological disorders.

Keywords:

FIRES Inflammation anti-inflammatory epilepsy status epilepticus

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Published on: December 7, 2017

Area of Science:

Neurology
Immunology
Dietary Science

Background:

The ketogenic diet (KD) is a proven therapy for drug-resistant epilepsy.
KD is being investigated for Febrile Infection-Related Epilepsy Syndrome (FIRES) and epileptic encephalopathies.
Evidence suggests KD targets immune system dysregulation in epilepsy.

Purpose of the Study:

To explore the anti-inflammatory and neuroprotective properties of the KD.
To investigate potential therapeutic applications of KD beyond epilepsy.

Main Methods:

Review of existing evidence on KD's effects on immune function.
Analysis of KD's impact in experimental models of neurological disorders.

Main Results:

KD demonstrates anti-inflammatory effects in models of multiple sclerosis, Parkinson's disease, pain, and spinal cord injury.
Potential mechanisms include ketone bodies, caloric restriction, fatty acids, and gut microbiota modulation.

Conclusions:

The KD possesses broad anti-inflammatory and neuroprotective properties.
KD shows promise for treating various neurological conditions by modulating immunity.