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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
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Circular RNAs: New players in thyroid cancer
Sarina Borran1, Gelavizh Ahmadi2, Samaneh Rezaei3
1School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pathology, Research and Practice
|September 28, 2020
Summary
Circular RNAs (circRNAs) are emerging as key players in thyroid cancer development and progression. These molecules show potential as diagnostic and therapeutic biomarkers for this increasingly common endocrine malignancy.
Area of Science:
- Endocrinology
- Molecular Biology
- Oncology
Background:
- Thyroid cancer, the most common endocrine malignancy, is increasing in prevalence.
- While often indolent, some thyroid cancers can become lethal, necessitating research into their underlying mechanisms.
- Circular RNAs (circRNAs), a class of non-coding RNAs, are increasingly identified in cancer tissues.
Purpose of the Study:
- To summarize the role of circRNAs in thyroid cancer pathogenesis.
- To highlight circRNAs as potential diagnostic and therapeutic biomarkers for thyroid cancer.
- To review the involvement of circRNAs in the broader context of various cancers.
Main Methods:
- Literature review and synthesis of existing research on circRNAs in thyroid cancer.
- Analysis of circRNA functions, including microRNA/ceRNA sponging, protein interaction, and gene regulation.
- Examination of circRNAs' roles in cellular mechanisms relevant to cancer, such as apoptosis, angiogenesis, and invasion.
Main Results:
- CircRNAs function as either oncogenes or tumor suppressors in thyroid cancer.
- CircRNAs regulate critical cellular processes involved in thyroid cancer pathogenesis through microRNA and protein sponging.
- These molecules are implicated in tumor growth and invasion.
Conclusions:
- CircRNAs represent promising biomarkers for the prognosis and diagnosis of thyroid cancer.
- Understanding circRNA mechanisms offers potential therapeutic strategies for thyroid cancer.
- CircRNAs play a significant role in the pathogenesis of diverse cancers.
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