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Pancreatic Ductal Adenocarcinoma
Jasreman Dhillon1,2, Michel Betancourt3
1Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, Florida, USA, Jasreman.Dhillon@moffitt.org.
Monographs in Clinical Cytology
|September 28, 2020
Summary
This review focuses on diagnosing pancreatic ductal adenocarcinoma (PDAC), the most common pancreatic cancer, using fine-needle aspiration. It covers cytological findings, related carcinomas, and diagnostic aids for accurate cancer diagnosis.
Area of Science:
- Cytopathology
- Surgical Pathology
- Gastroenterology
Background:
- Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy.
- Fine-needle aspiration (FNA) is frequently used to diagnose PDAC.
- Accurate cytological diagnosis is crucial due to implications for patient treatment, including pancreatic resection.
Purpose of the Study:
- To review the cytological findings of PDAC and other carcinomas of ductal lineage.
- To provide information on clinical features, histology, and serum markers.
- To discuss differential diagnoses, diagnostic pitfalls, and ancillary studies for cytopathologists.
Main Methods:
- Review of cytological findings in PDAC and related ductal carcinomas.
- Analysis of morphological variations and distinct entities.
- Discussion of clinical features, histology, serum markers, and ancillary studies.
Main Results:
- Detailed description of cytological features for PDAC.
- Categorization of morphologically distinct and related carcinomas of ductal lineage.
- Identification of key diagnostic challenges and useful ancillary tests.
Conclusions:
- Accurate cytological diagnosis of PDAC is essential for patient management.
- Familiarity with various ductal lineage carcinomas improves diagnostic accuracy.
- This review equips cytopathologists with information for clinically valuable diagnoses.
