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Related Concept Videos

Obesity01:24

Obesity

1000
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1000
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

96
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
96
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

134
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
134
Neurotransmitters01:31

Neurotransmitters

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Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

115
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
115
Regulation of Food Intake01:30

Regulation of Food Intake

2.0K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.0K

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Related Experiment Video

Updated: Dec 7, 2025

Control of Eating Behavior Using a Novel Feedback System
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Obesity and Brain Function: The Brain-Body Crosstalk.

Sophia X Sui1, Julie A Pasco1,2,3,4

  • 1IMPACT-The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC 3220, Australia.

Medicina (Kaunas, Lithuania)
|September 29, 2020
PubMed
Summary

Obesity, characterized by excess body fat, is linked to reduced brain function and dementia risk. Further research is needed to understand this complex body-brain connection.

Keywords:
BDNFbrain functioncognitive functioninflammationleptinobesity

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Area of Science:

  • Neuroscience
  • Public Health
  • Endocrinology

Background:

  • Dementia encompasses progressive neurocognitive disorders.
  • Obesity is a global health issue and a known risk factor for dementia.
  • The impact of obesity on the brain and central nervous system is a growing area of research.

Purpose of the Study:

  • To review evidence on body-brain crosstalk concerning obesity and brain function.
  • To identify key research methodologies and measurements in this field.
  • To highlight research gaps for future systematic reviews and empirical studies.

Main Methods:

  • Literature review of existing studies on obesity and brain function.
  • Analysis of research measurements and methodologies.
  • Identification of biological mechanisms and risk factors.

Main Results:

  • Obesity is associated with impaired brain function.
  • Research in this area faces challenges due to the complexity of obesity and the brain.
  • Inconsistencies in definitions and measurement techniques affect the reliability of findings.

Conclusions:

  • Obesity appears to negatively impact brain function.
  • The relationship between obesity and brain health is complex and requires further investigation.
  • Advanced research techniques can enhance future studies on the obesity-brain axis.