Related Experiment Video
Updated: Dec 7, 2025

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
Published on: June 21, 2021
Redox Regulation of STAT1 and STAT3 Signaling
Elena Butturini1, Alessandra Carcereri de Prati1, Sofia Mariotto1
1Department of Neuroscience, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy.
Abstract:
STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation of specific sets of genes. Despite being activated downstream of common cytokine and growth factors, STAT1 and STAT3 play essentially antagonistic roles and the disruption of their balance directs cells from survival to apoptotic cell death or from inflammatory to anti-inflammatory responses. Different mechanisms are proposed to explain this yin-yang relationship. Considering the redox aspect of STATs proteins, this review attempts to summarize the current knowledge of redox regulation of STAT1 and STAT3 signaling focusing the attention on the post-translational modifications that affect their activity.
Related Concept Videos
The JAK-STAT Signaling Pathway
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Regulation of the Unfolded Protein Response
Co-activators and Co-repressors
Redox Reactions
Redox Reactions

