[Long-term outcome after endoscopic resection for early colorectal carcinoma]

Area of Science:

• Gastroenterology
• Oncology
• Surgical Endoscopy

Background:

• Early colorectal carcinoma (ECC) presents a growing challenge in gastrointestinal oncology.
• Endoscopic resection has emerged as a minimally invasive treatment option for ECC.
• Understanding the long-term outcomes and risk factors associated with endoscopic resection is vital for patient management.

Purpose of the Study:

• To analyze clinical and follow-up data of early colorectal carcinoma (ECC) patients treated with endoscopic resection.
• To evaluate the long-term outcomes and disease-free survival rates following endoscopic resection for ECC.
• To identify risk factors influencing the prognosis of ECC after endoscopic resection.

Main Methods:

• Retrospective analysis of clinical and follow-up data from 550 patients with ECC undergoing endoscopic resection between June 2008 and June 2016.
• Investigation of factors influencing disease-free survival, including submucosal invasion depth, tumor differentiation, vascular invasion, and margin status.
• Statistical analysis to determine the impact of risk factors on recurrence and metastasis.

Main Results:

• The mean follow-up duration was 60.7 months for 550 ECC patients.
• The overall 5-year disease-free survival rate was 98.8%, with 100% for curative resections and 93.3% for non-curative resections.
• Low incidence of recurrence (6 patients) and metastasis, with risk factors like deep submucosal invasion and positive margins correlating with increased risk.

Conclusions:

• Endoscopic resection provides favorable long-term outcomes for early colorectal carcinoma (ECC).
• The risk of lymph node metastasis in ECC treated endoscopically is notably low.
• Close post-treatment surveillance and tailored additional therapies for non-curative resections are essential to optimize therapeutic efficacy.