Related Experiment Video

Updated: Dec 7, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.7K

Epidemiology of Demyelinating Diseases in Korean Pediatric Patients

Hye Hyun Yoon1, Ji Young Park1, Su Yeong Kim1

  • 1Department of Pediatrics, 65542Chung-Ang University Hospital, Seoul, Korea.

Journal of Child Neurology
|September 29, 2020
PubMed

Insights

This study reveals the first comprehensive epidemiology of pediatric demyelinating diseases in South Korea. Guillain-Barré syndrome was most common, with seasonal and regional variations observed in children.

Area of Science:

  • Pediatric Neurology
  • Epidemiology
  • Demyelinating Diseases

Background:

  • Epidemiological data on pediatric demyelinating diseases in Korea is lacking.
  • Demyelinating diseases can significantly impact child health and development.

Purpose of the Study:

  • To determine the incidence and characteristics of pediatric demyelinating diseases in South Korea.
  • To analyze the epidemiology of acute-disseminated encephalomyelitis, multiple sclerosis, neuromyelitis optica, and Guillain-Barré syndrome in children.

Main Methods:

  • Utilized big data from the Korean Health Insurance Review and Assessment Service (HIRA).
  • Analyzed records of children aged 0-17 diagnosed between January 2010 and December 2017.
  • Examined disease prevalence, sex ratios, seasonality, and regional distribution.

Main Results:

  • 1722 children were included: 54.1% Guillain-Barré syndrome, 32.1% acute-disseminated encephalomyelitis, 9.9% multiple sclerosis, 3.9% neuromyelitis optica.
  • Male-female ratios varied by disease: higher in ADEM and GBS, lower in MS and NMO.
  • Peak prevalence occurred in summer, with significant regional differences noted, particularly in Seoul and Gyeonggi.

Conclusions:

  • This is the first study to report the incidence of pediatric demyelinating diseases in South Korea.
  • Findings highlight the importance of considering demographic, seasonal, and regional factors in pediatric demyelinating disease epidemiology.
  • Establishes a baseline for future research and public health strategies in Korea.

Keywords:
childrenencephalitisepidemiologymultiple sclerosispediatric

More Related Videos

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

9.5K
Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique09:37

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

2.1K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
131
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
165