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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Updated: Dec 7, 2025

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Towards stem cell-based neuronal regeneration for glaucoma.

Zi-Qi Hua¹, Hui Liu¹, Ningli Wang²

¹Laboratory of Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, The Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Progress in Brain Research

|September 29, 2020

Summary

Stem cell therapy offers a promising approach for glaucoma, a leading cause of blindness. This review explores the regeneration of retinal ganglion cells (RGCs) using various stem cells for potential glaucoma treatment.

Keywords:

Glaucoma Regeneration Retinal ganglion cells Stem cells Transplantation

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Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Published on: February 12, 2018

Area of Science:

Ophthalmology
Neuroscience
Regenerative Medicine

Background:

Glaucoma is a leading cause of irreversible blindness, characterized by retinal ganglion cell (RGC) apoptosis and optic nerve damage.
Current glaucoma treatments primarily focus on delaying disease progression, highlighting the need for regenerative therapies.
Elevated intraocular pressure and progressive visual field loss are key clinical features of glaucoma.

Purpose of the Study:

To review the current advancements in stem cell-based regeneration of retinal ganglion cells (RGCs) for glaucoma treatment.
To discuss the potential of pluripotent stem cell-derived RGCs in restoring vision.
To outline the future perspectives and challenges in RGC regeneration therapy for glaucoma.

Main Methods:

Review of existing literature on stem cell sources for RGC regeneration, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), and retinal progenitor cells (RPCs).
Analysis of studies focusing on RGC regeneration and transplantation strategies.
Examination of therapeutic approaches for glaucoma utilizing stem cell-derived RGCs.

Main Results:

Various stem cell types, including ESCs, iPSCs, MSCs, and RPCs, have demonstrated potential for RGC regeneration.
Pluripotent stem cells offer a viable source for generating RGCs for transplantation.
Significant progress has been made in developing stem cell-based strategies for glaucoma.

Conclusions:

Stem cell-based neuronal regeneration therapy holds significant promise for treating glaucoma.
RGC regeneration and transplantation are crucial for future glaucoma treatment modalities.
Further research is needed to overcome challenges and optimize stem cell therapies for glaucoma.