Related Experiment Video
Updated: Dec 7, 2025

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
A randomized controlled trial of an online immunization curriculum
Barbara Pahud1, S Elizabeth Williams2, Brian R Lee1
1Children's Mercy Hospital, Department of Pediatrics, UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, United States.
The Collaboration for Vaccination Education and Research (CoVER) curriculum effectively improved vaccine knowledge and resident confidence in discussing immunizations. This online program offers a standardized approach to physician-in-training education, addressing concerns in clinical practice.
Area of Science:
- Medical Education
- Public Health
- Vaccinology
Background:
- Physician immunization education lacks standardization across residency programs.
- Addressing vaccine concerns in clinical practice requires robust training for physicians-in-training.
- The Collaboration for Vaccination Education and Research (CoVER) developed an online curriculum to standardize this education for pediatric and family medicine residents.
Purpose of the Study:
- To evaluate the effectiveness of the CoVER online curriculum in improving vaccine knowledge, attitudes/hesitancy, and self-confidence among physicians-in-training.
- To assess the impact of a standardized online immunization education program compared to standard training.
Main Methods:
- A cluster randomized controlled trial (RCT) was conducted with 1444 residents across 31 programs.
- The intervention group received the CoVER online curriculum; the control group received standard education.
- Outcomes measured included changes in vaccine knowledge, attitudes/hesitancy, and self-confidence via pre- and post-intervention surveys, analyzed using hierarchical general linear models.
Main Results:
- Overall vaccine knowledge scores increased in both groups, with greater gains observed in the CoVER group for family medicine residents (p=0.041).
- Vaccine hesitancy was more prevalent in family medicine residents (23%) than pediatric residents (10%).
- Residents in the CoVER group demonstrated significantly greater increases in self-confidence discussing vaccines with patients/parents across all residency years (p<0.03).
Conclusions:
- The CoVER curriculum is an effective model for standardizing immunization education for physicians-in-training.
- This RCT supports the CoVER curriculum's ability to enhance resident confidence in vaccine communication.
- Standardized online curricula can improve essential skills for addressing vaccine concerns in clinical settings.
Related Concept Videos
Vaccinations
Randomized Experiments
Simple randomization
Simple...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Community Based Intervention
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

