[Diffuse cutaneous mastocytosis. Apropos of 2 familial cases]

The observation of two cases of diffuse cutaneous mastocytosis (DCM) with familiar characteristics in a man and his daughter, with only diffuse infiltration of the skin in the former and the girl also with blister and gastrointestinal participation, was the reason to do histological and ultrastructural studies. The authors observed a good therapeutic response to ketotifen and cyproheptadine, although the dose was higher than the usual one.