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Contribution of Matrix Metalloproteinase-9 rs3918242 Genotypes to Childhood Leukemia Risk

Chien-Chung Kuo1, Chia-Wen Tsai2,3, Wen-Shin Chang2,3

  • 1Department of Pediatric Orthopedics, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Anticancer Research
|September 29, 2020
PubMed
Abstract

Insights

Metalloproteinase-9 (MMP-9) rs3918242 genotypes do not significantly increase childhood acute lymphocytic leukemia (ALL) risk. Further research is needed to explore potential indirect influences and underlying mechanisms in diverse populations.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Previous research indicated a link between metalloproteinase-9 (MMP-9) promoter genotypes and adult acute lymphocytic leukemia (ALL).
  • No studies have investigated this association in the context of childhood ALL.
  • The MMP-9 gene plays a role in various biological processes, including inflammation and tissue remodeling, which could be relevant to cancer development.

Purpose of the Study:

  • To investigate the association between the MMP-9 rs3918242 polymorphism and the risk of childhood ALL.
  • To determine if specific MMP-9 genotypes are correlated with an increased susceptibility to childhood ALL in a Taiwanese population.

Main Methods:

  • A case-control study was conducted involving 266 children diagnosed with ALL and 266 age- and sex-matched healthy controls from Taiwan.
  • Genotyping of the MMP-9 rs3918242 polymorphism was performed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Main Results:

  • No statistically significant difference in the frequency of MMP-9 rs3918242 genotypes (CT or TT vs. CC) was observed between childhood ALL cases and healthy controls.
  • Allelic frequency analysis revealed that the variant T allele of MMP-9 rs3918242 was not differentially distributed between the case and control groups.
  • The study found no significant association between MMP-9 rs3918242 genotypes and the risk of developing childhood ALL.

Conclusions:

  • The MMP-9 rs3918242 genotypes do not appear to be a significant risk factor for childhood ALL in the studied Taiwanese population.
  • While direct association was not found, the study suggests that MMP-9 genotypes might indirectly influence childhood ALL risk through complex mechanisms.
  • Further large-scale validation studies in diverse ethnic groups and detailed mechanistic investigations are warranted to fully elucidate the role of MMP-9 in childhood ALL.
Keywords:
Acute lymphocytic leukemiaMMP-9Taiwancase–control studychildhoodgenotypepolymorphism

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