Advanced appendiceal goblet cell carcinoids with intestinal obstruction: two case reports

Area of Science:

• Gastroenterology
• Oncology
• Pathology

Background:

• Goblet cell carcinoid is a rare appendiceal neoplasm characterized by a combination of carcinoid and adenocarcinoma-like features.
• This rare tumor presents diagnostic and therapeutic challenges in clinical practice.

Observation:

• Two cases of advanced goblet cell carcinoid originating in the appendix are presented.
• Case 1: 48-year-old male with abdominal distension. Case 2: 64-year-old female with constipation.
• Both patients presented with metastatic disease to the peritoneum and other organs at diagnosis, precluding radical surgery.

Findings:

• Chemotherapy regimens for colon cancer were administered with limited efficacy.
• Both patients developed intestinal obstruction due to peritoneal dissemination, leading to a poor prognosis and death within months.
• Current chemotherapy strategies for goblet cell carcinoids lack consensus.

Implications:

• The study underscores the aggressive nature of metastatic goblet cell carcinoid.
• There is a critical need for further research to establish effective therapeutic strategies for this rare appendiceal cancer.
• Development of standardized treatment protocols is essential for improving patient outcomes.