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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

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Clear cell acanthoma.

Gunnar Wagner¹, Walter Back², Michael Max Sachse¹

¹Department of Dermatology, Allergology and Phlebology, Hospital Bremerhaven-Reinkenheide, Bremerhaven, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

|September 29, 2020

Summary

This summary is machine-generated.

Clear cell acanthoma is a rare skin tumor often missed due to varied appearance. Diagnosis relies on specific histopathology showing pale keratinocytes and unique dermoscopic "string of pearls" vessels.

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Area of Science:

Dermatology
Dermatopathology

Background:

Clear cell acanthoma is a rare skin neoplasm with variable clinical presentation.
Diagnosis is often delayed due to uncharacteristic initial clinical findings.

Purpose of the Study:

To highlight the diagnostic features of clear cell acanthoma.
To discuss its classification and differential diagnosis.

Main Methods:

Review of clinical, dermoscopic, and histopathological findings in clear cell acanthoma.
Analysis of current literature regarding its etiology, pathogenesis, and classification.

Main Results:

Clear cell acanthoma presents as a small, red papule, typically on lower extremities.
Dermoscopy reveals a "string of pearls" vascular pattern, a specific diagnostic clue.
Histopathology shows compact acanthosis with pale, PAS-reactive keratinocytes.

Conclusions:

Clear cell acanthoma requires histopathological confirmation due to subtle clinical signs.
Its classification remains debated, with ongoing discussion on whether it is a neoplasia or reactive dermatosis.