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A reappraisal on botulinum toxin-a in trigeminal neuralgia

Alfio Spina1, Luigia Brugliera2, Filippo Gagliardi3

  • 1Department of Neurosurgery and Gamma Knife Radiosurgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy - spina.alfio@hsr.it.

Journal of Neurosurgical Sciences
|September 29, 2020
PubMed
Abstract

No abstract available in PubMed .

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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