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Updated: Dec 7, 2025
The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood
Published on: February 7, 2025
Rationale Use of Neutrophil-to-lymphocyte ratio for early diagnosis and stratification of COVID-19
Insights
The neutrophil-lymphocyte ratio (NLR) may help detect COVID-19 early and indicate disease severity. This marker is investigated for diagnosing and stratifying coronavirus disease 2019 (COVID-19) cases.
Area of Science:
- Infectious Diseases
- Hematology
- Critical Care Medicine
Background:
- Coronavirus disease 2019 (COVID-19) is a global pandemic caused by SARS-CoV-2.
- The virus primarily impacts the human respiratory system, potentially leading to severe complications and death.
- Understanding biomarkers for early detection and prognosis is crucial.
Purpose of the Study:
- To analyze the role of the neutrophil-lymphocyte ratio (NLR) in viral infections, with a focus on COVID-19.
- To investigate NLR as a potential surrogate marker for the diagnosis and stratification of COVID-19.
- To assess NLR's utility in reflecting disease progression and severity.
Main Methods:
- Review of existing literature on neutrophil-lymphocyte ratio (NLR) in viral infections.
- Analysis of NLR's correlation with COVID-19 diagnosis and severity.
- Exploration of NLR as a prognostic indicator for SARS-CoV-2 infection.
Main Results:
- Neutrophil-lymphocyte ratio (NLR) may serve as an early detection marker for COVID-19.
- Elevated NLR levels may correlate with disease progression and increased severity.
- NLR could be a valuable tool for stratifying patients with coronavirus disease.
Conclusions:
- The neutrophil-lymphocyte ratio (NLR) shows potential as a diagnostic and prognostic biomarker for COVID-19.
- Further research is warranted to validate NLR's role in clinical decision-making for coronavirus disease.
- NLR may aid in identifying patients at risk for severe outcomes from SARS-CoV-2 infection.
Abstract:
Coronavirus disease is caused by a virus that is the cause of a potentially fatal disease worldwide. Coronavirus is a pathogen that primarily affects the human respiratory system. Coronavirus 2019 (COVID-19) has been named WHO since February 11, 2020. The first cases of COVID-19 were reported in December 2019. In January 2020, COVID-19 infection was identified in hospitalized patients in Wuhan, China. We analyze the role of neutrophil-lymphocyte ratio (NLR) in viral infection with special emphasize on novel corona virus disease-COVID-19. NLR may be used for early detection and may reflect progression to the more severe illness leading to SARS-CoV-2. In the mini review we investigate the use of NLR as a surrogate marker for diagnosis and stratification of COVID-19.Clinical symptoms such as pneumonia, acute respiratory distress syndrome, acute heart damage have led to death. In some cases, multiple inflammations have been observed. Treatment with interferon inhalation showed no clinical effect and the condition worsened instead (Tab. 5, Fig. 1, Ref. 18). Keywords: neutrophil-to-lymphocyte ratio, corona virus SARS-CoV-2, COVID-19.
