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Protective Effect of Resveratrol against Glioblastoma: A Review
Milad Ashrafizadeh1, Reza Mohammadinejad2, Tahereh Farkhondeh3
1Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956 Istanbul, Turkey.
Background:
One of the most common tumors of the central nervous system is Glioblastoma (GBM).
Objective:
There is not still an appropriate cure for this malignant tumor. Plant-derived natural products have demonstrated great potential in cancer therapy, and Resveratrol (Res) is among them. Therefore, the current study focused on the protective effect of resveratrol against glioblastoma and its underlying mechanism.
Methods:
PubMed, Medline, Scopus, Web of Science, and Google Scholar were searched by using the following keywords: Resveratrol, Glioblastoma, Brain tumor, Cancer therapy, Medicinal herbs to July 2020.
Results:
Res is a non-flavonoid polyphenol responsible for the protection of plants against pathogen attacks. Res has multiple pharmacological effects, including antioxidant, anti-inflammatory, anti-diabetic, and anti-tumor. Res is capable of penetration into the blood-brain barrier, making it suitable for brain tumor therapy. Besides, Res targets various molecular signaling pathways in cancer therapy.
Conclusion:
In the present review, it was found that Res administration is beneficial in GBM therapy by inhibition of proliferation, viability, and migration via modulation of molecular pathways.
Insights
Resveratrol (Res) shows promise in treating Glioblastoma (GBM), a common brain tumor. This natural compound inhibits GBM cell growth and migration by affecting key molecular pathways.
Area of Science:
- Neuro-oncology
- Natural product chemistry
- Molecular pharmacology
Background:
- Glioblastoma (GBM) is a prevalent and aggressive central nervous system tumor.
- Current treatments for GBM remain insufficient, necessitating novel therapeutic strategies.
Purpose of the Study:
- To investigate the potential therapeutic effects of Resveratrol (Res) against Glioblastoma (GBM).
- To elucidate the underlying molecular mechanisms of Resveratrol's action in GBM therapy.
Main Methods:
- A comprehensive literature search was conducted across major scientific databases (PubMed, Scopus, Web of Science, Google Scholar).
- Keywords included Resveratrol, Glioblastoma, Brain tumor, Cancer therapy, and Medicinal herbs, with data collected up to July 2020.
Main Results:
- Resveratrol, a plant-derived polyphenol, exhibits antioxidant, anti-inflammatory, and anti-tumor properties.
- Its ability to cross the blood-brain barrier makes it a suitable candidate for brain tumor treatment.
- Resveratrol modulates various molecular signaling pathways crucial in cancer progression.
Conclusions:
- Resveratrol administration demonstrates therapeutic benefits in Glioblastoma (GBM) treatment.
- It effectively inhibits GBM cell proliferation, viability, and migration through molecular pathway modulation.
