Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

39.2K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
39.2K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

4.9K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.9K
Prokaryotic Cells01:28

Prokaryotic Cells

47.4K
Prokaryotes are small unicellular organisms that include the domains — Archaea and Bacteria. Bacteria include many common microorganisms, such as Salmonella and E. coli, while the Archaea include extremophiles that live in harsh environments, such as volcanic springs.
Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize...
47.4K
Prokaryotic Cells01:51

Prokaryotic Cells

131.7K
Prokaryotes are small unicellular organisms that include the domains—Archaea and Bacteria. Bacteria include many common organisms, such as Salmonella and E. coli, while the Archaea include extremophiles that live in harsh environments, such as volcanic springs.
Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize proteins....
131.7K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.5K
Bacterial Growth Curve01:28

Bacterial Growth Curve

1.7K
The bacterial growth curve is a fundamental concept in microbiology that describes the dynamics of bacterial population growth in a closed system with controlled environmental conditions, such as temperature and nutrient availability. This curve is divided into four distinct phases: lag, log (exponential), stationary, and death phases, each reflecting a unique stage of bacterial adaptation and growth. During the lag phase, bacteria acclimate to their surroundings by synthesizing essential...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A deep learning approach to predicting hospitalized patients' SEIRD states using multimodal spatiotemporal data.

International journal of medical informatics·2025
Same author

Discovering multiple antibiotic resistance phenotypes using diverse top-k subgroup list discovery.

Artificial intelligence in medicine·2025
Same author

Infection Spread and Outbreaks Support with Spatial-Temporal Visualization Tool for Hospitals.

Journal of medical systems·2025
Same author

Cell cycle regulation in Escherichia coli: from governing principles, checkpoints, and control variables to molecular mechanisms.

Current opinion in microbiology·2025
Same author

The pathway to resolve dimeric forms distinguishes plasmids from megaplasmids in Enterobacteriaceae.

Nucleic acids research·2025
Same author

Interplay between the Xer recombination system and the dissemination of antibioresistance in Acinetobacter baumannii.

Nucleic acids research·2025

Related Experiment Video

Updated: Dec 7, 2025

Measuring Proliferation of Vascular Smooth Muscle Cells Using Click Chemistry
07:17

Measuring Proliferation of Vascular Smooth Muscle Cells Using Click Chemistry

Published on: October 30, 2019

7.1K

Bacterial cell proliferation: from molecules to cells.

Alix Meunier1, François Cornet1, Manuel Campos1

  • 1Centre de Biologie Intégrative de Toulouse (CBI Toulouse), Laboratoire de Microbiologie et Génétique Moléculaires (LMGM), Université de Toulouse, UPS, CNRS, IBCG, 165 rue Marianne Grunberg-Manago, 31062 Toulouse, France.

FEMS Microbiology Reviews
|September 29, 2020
PubMed
Summary
This summary is machine-generated.

Bacteria efficiently proliferate due to robust cell cycles synchronized with growth. Understanding the complex regulatory networks coordinating DNA replication, division, and cell growth is crucial for accurate modeling.

Keywords:
adderbacterial cell proliferationcell cycle regulationresource allocationspatio-temporal coordination

More Related Videos

Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines
12:35

Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

Published on: September 3, 2016

19.9K
Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

61.1K

Related Experiment Videos

Last Updated: Dec 7, 2025

Measuring Proliferation of Vascular Smooth Muscle Cells Using Click Chemistry
07:17

Measuring Proliferation of Vascular Smooth Muscle Cells Using Click Chemistry

Published on: October 30, 2019

7.1K
Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines
12:35

Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

Published on: September 3, 2016

19.9K
Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

61.1K

Area of Science:

  • Bacterial cell biology
  • Microfluidics
  • Systems biology

Background:

  • Bacterial cell proliferation relies on efficient growth and low-error multiplication.
  • Cell cycle robustness and synchronization with growth and cytokinesis are key.
  • Single-cell physiology in microfluidics reveals simple models of cell size, growth, and cell cycle coupling.

Purpose of the Study:

  • To contrast simple phenomenological models with complex underlying regulatory networks in bacterial cell cycles.
  • To explore mechanisms coordinating DNA replication, segregation, cell division, and cell growth.
  • To emphasize the importance of molecular mechanisms for creating verifiable models.

Main Methods:

  • Analysis of single-cell physiology data from microfluidic experiments.
  • Phenomenological modeling of cell size, growth, and cell cycle.
  • Review and synthesis of known regulatory networks and crosstalk between cellular processes.

Main Results:

  • Apparent simplicity of models (e.g., constant size addition) belies complex regulatory networks.
  • Coordination of DNA and division cycles with cell growth involves numerous mechanisms beyond checkpoints.
  • Crosstalk between DNA replication/segregation, division, and cell growth is a central theme.

Conclusions:

  • Precise knowledge of molecular mechanisms is critical for understanding bacterial cell cycle control.
  • Integrating diverse control layers across scales requires detailed understanding of underlying molecular interactions.
  • Synthetic and verifiable models necessitate a deep dive into the molecular intricacies of bacterial proliferation.