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Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells
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Pine bark (Pinus spp.) extract for treating chronic disorders.

Nina U Robertson1, Anel Schoonees2, Amanda Brand2

  • 1Division of Human Nutrition, Stellenbosch University, Cape Town, South Africa.

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|September 29, 2020
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This summary is machine-generated.

This review found insufficient evidence to conclude on the efficacy or safety of pine bark extract supplements for various chronic disorders due to small sample sizes and limited studies. More research is needed to determine its benefits.

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Area of Science:

  • Nutritional Science
  • Pharmacology
  • Evidence-Based Medicine

Background:

  • Pine bark extract, rich in antioxidants like proanthocyanidins, is marketed for chronic conditions linked to oxidative stress.
  • This review is an update of previous research on pine bark extract supplements.

Purpose of the Study:

  • To evaluate the effectiveness and safety of pine bark extract supplements for treating a range of chronic disorders.

Main Methods:

  • Conducted a systematic review of randomized controlled trials (RCTs) across 10 chronic disorders.
  • Searched multiple databases and trial registries, contacting manufacturers for additional studies.
  • Assessed trial eligibility, data extraction, risk of bias, and synthesized findings, using GRADE for evidence certainty.

Main Results:

  • Included 27 RCTs with 1641 participants across asthma, ADHD, CVD, CVI, diabetes, erectile dysfunction, sexual dysfunction, osteoarthritis, osteopenia, and TBI.
  • For most conditions, the evidence was of very low certainty, with no definitive conclusions on efficacy or safety.
  • Limited data and reporting issues prevented firm conclusions for specific conditions like asthma, ADHD, CVD, and diabetes.

Conclusions:

  • Small sample sizes, few RCTs per condition, varied outcome measures, and poor reporting limit definitive conclusions.
  • The efficacy and safety of pine bark extract supplements for chronic disorders cannot be determined from current evidence.
  • Further high-quality research is required to establish the benefits and risks of pine bark extract.