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Long-term respiratory outcomes of post-op congenital lung malformations

Alican Dincel1, Cansu Yilmaz Yegit2, Almala Pinar Ergenekon2

  • 1Department of Pediatrics, School of Medicine, Marmara University, Istanbul, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|September 29, 2020
PubMed

Insights

Children who underwent surgery for congenital lung malformations (CLM) show long-term pulmonary function impairment. The Lung Clearance Index (LCI) may detect airway disease earlier than spirometry in these patients.

Area of Science:

  • Pediatric Pulmonology
  • Thoracic Surgery
  • Respiratory Physiology

Background:

  • Congenital lung malformations (CLM) are rare conditions requiring surgical intervention.
  • Long-term outcomes of surgical treatment for CLM are not fully understood.
  • Evaluating post-surgical lung function in pediatric CLM patients is crucial.

Purpose of the Study:

  • To assess and compare the long-term pulmonary function of children with CLM after surgery against healthy controls.
  • To investigate the utility of spirometry and Lung Clearance Index (LCI) in evaluating lung function in this cohort.

Main Methods:

  • A cohort of 16 children with CLM (post-surgery) and 30 healthy controls were enrolled.
  • Demographic data were collected for both groups.
  • Pulmonary function was assessed using spirometry (FEV1, FVC, FEF25-75) and nitrogen-based Lung Clearance Index (LCI).

Main Results:

  • Patients with CLM exhibited significantly lower FEV1, FVC, and FEF25-75 compared to healthy controls.
  • The LCI was significantly higher in the CLM group (8.33 ± 1.52) than in controls (7.28 ± 0.80).
  • A strong inverse correlation was observed between LCI and FEV1/FVC in patients with CLM.

Conclusions:

  • Surgical treatment for CLM is associated with long-term pulmonary function deficits in children.
  • The Lung Clearance Index (LCI) shows potential as a more sensitive marker for early airway disease detection in post-surgical CLM patients than traditional spirometry.
Abstract

Keywords:
congenital lung malformationslung clearance indexpulmonary function testspirometry

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