Carboxyl-Assisted meta-Selective C-H Functionalizations of Benzylsulfonamides
Lei Cai1,2, Shangda Li1, Chunlin Zhou1,2
1Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.
Abstract:
A protocol of carboxyl-group-assisted, Pd(II)-catalyzed remote meta-C(sp2)-H olefination and arylation of benzylsulfonamides has been developed. It was supposed to proceed through a κ2 coordination of the carboxyl group to the Pd center. These findings demonstrated the versatility of carboxyl-assisted remote meta-C-H activation strategy and might stimulate the exploration of novel reactivity and selectivity of other traditional chelating groups in different contexts.
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