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Evaluation of Mesorectal Microcirculation With Quantitative Dynamic Contrast-Enhanced MRI
Xinyue Yang1, Yiyan Liu2, Yan Chen2
1Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
AJR. American Journal of Roentgenology
|September 29, 2020
Summary
Rectal cancer alters mesorectal microcirculation, increasing blood flow around tumors. This blood flow decreases with nodal involvement, indicating potential for diagnostic MRI markers.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Rectal cancer significantly impacts surrounding tissues.
- Understanding mesorectal microcirculation is crucial for diagnosis and treatment planning.
Purpose of the Study:
- To quantitatively evaluate mesorectal microcirculation in rectal cancer patients using dynamic contrast-enhanced MRI (DCE-MRI).
- To assess the relationship between microcirculatory parameters and clinicopathologic features of rectal cancer.
Main Methods:
- 53 rectal cancer patients underwent preoperative 3-T DCE-MRI.
- Regions of interest were defined in tumor-surrounding and normal mesorectum.
- Key DCE-MRI parameters (Ktrans, kep, Ve) were calculated.
- Histopathology served as the reference standard.
Main Results:
- Tumor-surrounding mesorectum exhibited significantly higher Ktrans and Ve compared to normal mesorectum (p < 0.001).
- Lower Ktrans was observed in tumor-surrounding mesorectum with malignant lymph nodes (p = 0.034).
- A trend towards higher kep was seen in earlier stage tumors (p = 0.047).
Conclusions:
- Rectal tumors enhance mesorectal microcirculation, indicated by increased Ktrans and Ve.
- Nodal involvement is associated with decreased microcirculatory blood flow (Ktrans) in the tumor-surrounding mesorectum.
- DCE-MRI parameters may offer insights into rectal cancer progression and nodal status.
