Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.5K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.5K
Epigenetic Regulation01:46

Epigenetic Regulation

33.0K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.0K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

6.6K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
6.6K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.4K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.4K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.9K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.0K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between HPV-16 and HPV-18 viral loads and severity of cervical pre-invasive lesions in women with and without HIV in Botswana.

Frontiers in oncology·2026
Same author

Human oncogenic herpesvirus latency proteins activate NEK2 to promote chromosomal instability and tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Protocol to investigate replication kinetics of Kaposi's sarcoma-associated herpesvirus using single-molecule analysis of replicated DNA.

STAR protocols·2025
Same author

Sinonasal Inverted Papilloma and Clinical Significance of Dysplasia: A Multi-Institutional Study.

The Laryngoscope·2025
Same author

The 3D Genome Browser 2.0: an enhanced online platform for visualizing and analyzing 3D genome architecture.

Nucleic acids research·2025
Same author

Cervical and Tumor-Associated Microbiomes in Botswana Women With and Without HIV With Carcinoma of the Cervix Before and After Definitive Chemoradiation.

JCO global oncology·2025

Related Experiment Video

Updated: Dec 7, 2025

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
13:22

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining

Published on: January 23, 2014

18.6K

Herpesvirus Epigenetic Reprogramming and Oncogenesis.

Yonggang Pei1, Josiah Hiu-Yuen Wong1, Erle S Robertson1

  • 1Departments of Otorhinolaryngology-Head and Neck Surgery and Microbiology, Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

Annual Review of Virology
|September 29, 2020
PubMed
Summary

Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are oncogenic viruses. This review explores how their epigenetic modifications drive cancer, detailing mechanisms and cellular events involved.

Keywords:
EBVKSHVepigeneticsherpesvirusesoncogenesisreprogramming

More Related Videos

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus
06:14

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus

Published on: May 13, 2021

7.2K
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.2K

Related Experiment Videos

Last Updated: Dec 7, 2025

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
13:22

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining

Published on: January 23, 2014

18.6K
Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus
06:14

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus

Published on: May 13, 2021

7.2K
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.2K

Area of Science:

  • Virology and Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are human gammaherpesviruses classified as biological carcinogens.
  • These viruses are known to induce an oncogenic phenotype, contributing to various cancers.
  • While their oncogenic roles are established, the precise epigenetic mechanisms and cellular events driving oncogenesis remain incompletely understood.

Purpose of the Study:

  • To review the roles of epigenetic modifications in the genomes of EBV and KSHV.
  • To elucidate the detailed mechanisms by which these viral epigenetic alterations mediate oncogenesis.
  • To provide a comprehensive overview of the molecular contributors and cellular events involved in gammaherpesvirus-induced oncogenesis.

Main Methods:

  • Literature review focusing on epigenetic modifications of viral genomes.
  • Analysis of studies investigating DNA methylation, histone modification, chromatin remodeling, and noncoding RNA expression in EBV and KSHV.
  • Synthesis of current knowledge on cellular events and molecular pathways critical for oncogenesis induced by these viruses.

Main Results:

  • Epigenetic modifications, including DNA methylation and histone alterations, play significant roles in the oncogenesis mediated by EBV and KSHV.
  • Noncoding RNA expression is also implicated in the epigenetic regulation of these viral genomes during cancer development.
  • The review highlights the complexity of viral-induced oncogenesis, involving intricate interactions between viral epigenetics and host cellular machinery.

Conclusions:

  • Epigenetic modifications of EBV and KSHV genomes are critical for inducing the oncogenic phenotype.
  • Understanding these epigenetic strategies is essential for deciphering the complex mechanisms of gammaherpesvirus-associated cancers.
  • Further research into these viral epigenetic landscapes may reveal novel therapeutic targets for treating EBV- and KSHV-driven malignancies.