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Association between Physical Activity and Mortality in Patients with Claudication
Andrew W Gardner1, Odessa Addison, Leslie I Katzel
1Department of Physical Medicine and Rehabilitation, Penn State College of Medicine, Hershey, PA.
Medicine and Science in Sports and Exercise
|September 29, 2020
Summary
Light-intensity physical activity significantly lowers mortality risk in peripheral artery disease (PAD) patients with claudication. Even light activity offers substantial survival benefits, highlighting its importance beyond mobility.
Area of Science:
- Cardiovascular Health
- Exercise Physiology
- Public Health
Background:
- Peripheral artery disease (PAD) with claudication significantly impacts patient mortality.
- Understanding the role of physical activity intensity is crucial for managing PAD outcomes.
Purpose of the Study:
- To investigate the association between light-intensity physical activity and all-cause and cardiovascular mortality in PAD patients with claudication.
- To compare mortality risks across different physical activity levels (sedentary, light, moderate-to-vigorous).
Main Methods:
- A cohort of 386 PAD patients with claudication were classified by baseline physical activity levels.
- Mortality data (all-cause and cardiovascular) were tracked for up to 18.7 years using national registries.
- Statistical analysis, including hazard ratios, determined the impact of physical activity on survival.
Main Results:
- Light-intensity physical activity was associated with a ~50% lower risk of all-cause and cardiovascular mortality (HR=0.523, P=0.0007; HR=0.511, P=0.0113).
- Moderate-to-vigorous physical activity showed even greater risk reduction (58% all-cause, 66% cardiovascular).
- Sedentary patients exhibited the highest mortality rates.
Conclusions:
- Light-intensity physical activity is a significant protective factor against mortality in PAD patients with claudication.
- These findings support light physical activity as a vital, accessible intervention for improving survival in this high-risk population.
- The benefits extend beyond ambulation, emphasizing its broader health impact.
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