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Paraneoplastic Conjunctival Acanthosis Nigricans: A Case Report
Natalie Huang1, Han Y Yin, Robert Swan
1Department of Ophthalmology and Visual Sciences, State University of New York, Upstate Medical University, Syracuse, NY.
Purpose:
To report a patient who presented with red eye and diffuse palpebral conjunctival thickening and papillary growth bilaterally.
Methods:
A 63-year-old woman with a medical history of stage IV adenocarcinoma of the lung with metastasis to the bone, the lung, and the lymph nodes presented with redness and irritation of both eyes for 3 months. The patient has been treated with topical corticosteroids for 3 weeks with no relief of symptoms.
Results:
Clinical examination and pathology report of conjunctival biopsy confirmed the diagnosis of conjunctival acanthosis nigricans.
Conclusions:
Conjunctival acanthosis nigricans is a rare paraneoplastic condition that resembles papilloma and can present a challenge in diagnosis. When acanthosis nigricans occurs after the diagnosis of malignancy, it can be an indicator of progression of the underlying condition. The diagnosis of conjunctival acanthosis nigricans in a patient with no history of cancer should prompt clinicians for further malignancy workup.
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