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Paraneoplastic Conjunctival Acanthosis Nigricans: A Case Report
Natalie Huang1, Han Y Yin, Robert Swan
1Department of Ophthalmology and Visual Sciences, State University of New York, Upstate Medical University, Syracuse, NY.
Conjunctival acanthosis nigricans, a rare condition, presented as bilateral red eye and conjunctival thickening in a patient with lung cancer. This diagnosis can indicate malignancy progression or prompt cancer screening in new cases.
Area of Science:
- Ophthalmology
- Dermatology
- Oncology
Background:
- Acanthosis nigricans is a skin condition often associated with malignancy.
- Conjunctival involvement is rare and can mimic other ocular surface diseases.
Observation:
- A 63-year-old woman with stage IV lung adenocarcinoma presented with bilateral red eye and conjunctival thickening.
- Symptoms persisted despite topical corticosteroid treatment, suggesting an alternative diagnosis.
Findings:
- Conjunctival biopsy confirmed acanthosis nigricans.
- This finding in a cancer patient suggests potential malignancy progression.
Implications:
- Conjunctival acanthosis nigricans is a rare paraneoplastic sign.
- Its presence warrants consideration of underlying malignancy or progression of known cancer.
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