Osimertinib induced cardiomyopathy: A case report
Shun Shinomiya1, Kyoichi Kaira, Ou Yamaguchi
1Department of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center, Saitama University Hospital, 1397-1 Yamane, Hidaka-City, Saitama, Japan.
Medicine
|September 29, 2020
Summary
Osimertinib, used for advanced non-small cell lung cancer, can cause cardiomyopathy. Early recognition and drug withdrawal led to symptom improvement in a patient, highlighting the need for physician awareness.
Area of Science:
- Oncology
- Cardiology
- Pharmacology
Background:
- Osimertinib is a targeted therapy for advanced non-small cell lung cancer (NSCLC).
- While rare cardiotoxic effects like QT prolongation are known, osimertinib-induced cardiomyopathy is not well-documented.
- This case highlights a potential, albeit rare, adverse cardiac event associated with osimertinib therapy.
Observation:
- A patient with pulmonary adenocarcinoma experienced recurrence and was treated with osimertinib.
- Four months after initiating osimertinib, the patient developed fever and dyspnea.
- Endomyocardial biopsy confirmed non-specific cardiomyopathy, attributed to osimertinib.
Findings:
- The patient's cardiomyopathy symptoms and cardiac function improved after discontinuing osimertinib.
- Treatment with furosemide, carvedilol, and enalapril supported recovery.
- This suggests a direct causal link between osimertinib and the observed cardiomyopathy.
Implications:
- Physicians treating advanced NSCLC patients with osimertinib should monitor for signs of cardiomyopathy.
- Early diagnosis and withdrawal of osimertinib may prevent severe cardiac complications.
- Further research is warranted to understand the incidence and mechanisms of osimertinib-induced cardiomyopathy.
More Related Videos
09:32Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
Published on: October 17, 2025
233
09:38Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
Published on: June 26, 2019
8.3K
Related Concept Videos
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
234
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
234
01:25Cardiomyopathy I: Introduction and Classification
347
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
347
01:30Cardiomyopathy II: Dilated Cardiomyopathy
272
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
272
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
302
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
302
01:29Cardiomyopathy VI: Nursing Management
197
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
197
01:21Myocarditis I: Introduction
224
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
224