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Updated: Dec 7, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
Preparing for and responding to Covid-19's 'second hit'.
Shantanu Nundy1, Manmeet Kaur2, Prabhjot Singh3
1Accolade Inc, Plymouth Meeting, PA, United States; George Washington University, Milken Institute School of Public Health, Washington, DC, United States.
The Covid-19 pandemic causes indirect health consequences beyond direct infections. These disruptions in healthcare services lead to increased illness and death in the general patient population, termed the "second hit".
Area of Science:
- Public Health
- Epidemiology
- Healthcare Management
Background:
- Current Covid-19 mortality projections focus solely on direct patient impact.
- The broader, indirect effects of the pandemic on healthcare systems are largely overlooked.
Purpose of the Study:
- To highlight the significant, yet underestimated, indirect morbidity and mortality caused by Covid-19.
- To introduce and define the concept of the 'second hit' of Covid-19.
Main Methods:
- Conceptual analysis of pandemic-related healthcare disruptions.
- Review of existing Covid-19 impact assessments.
Main Results:
- Direct Covid-19 impact is only a fraction of the total expected morbidity and mortality.
- Disruptions to healthcare services create a 'second hit', increasing risks for non-Covid-19 patients.
Conclusions:
- The 'second hit' represents a critical, under-addressed consequence of the Covid-19 pandemic.
- Comprehensive public health strategies must account for both direct and indirect pandemic effects.
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