Clinical Relevance of Changes in Peripheral Blood Cells After Intracranial Aneurysm Rupture

Area of Science:

• Neuroscience
• Immunology
• Hematology

Background:

• Intracranial aneurysm (IA) rupture elicits a systemic immune and inflammatory reaction.
• Characterizing this systemic response is crucial for understanding patient outcomes.

Purpose of the Study:

• To characterize the systemic immune and inflammatory response following intracranial aneurysm rupture.
• To investigate the clinical utility of hematological parameters in assessing patient status and outcomes.

Main Methods:

• Analyzed mononuclear leukocytes using flow cytometry in 19 acute IA rupture patients and 20 controls.
• Calculated neutrophil-to-lymphocyte ratio (NL-R), lymphocyte-to-monocyte ratio (LM-R), platelet-to-lymphocyte ratio (PL-R), and systemic immune-inflammation index (SII).
• Correlated hematological parameters with clinical status (Glasgow Coma Scale, Hunt and Hess scale) and outcomes.

Main Results:

• Ruptured IA patients showed higher white blood cells, neutrophils, NL-R, and SII, with lower lymphocytes and LM-R compared to controls.
• Poor clinical status correlated with lower lymphocyte counts and higher NL-R, PL-R, and SII.
• Worse outcomes were associated with lower lymphocyte counts and higher PL-R.

Conclusions:

• Systemic immune and inflammatory responses are significant after IA rupture.
• Hematological parameters offer potential clinical utility for assessing IA rupture severity and outcomes.
• Further investigation into DN T cells and SII as clinical markers is warranted.