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[Clinicopathological features in relapsed diffuse large B-cell lymphoma].

Y X Gong1, Y F Yang1, Y F Feng1

  • 1Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|September 29, 2020
PubMed
Summary
This summary is machine-generated.

Relapsed diffuse large B-cell lymphoma (DLBCL) is often non-GCB type, with CD5 positivity and advanced stage being key indicators. Early screening for these clinical and pathological features can help identify patients at higher risk of recurrence.

Keywords:
Lymphoma, B-cellPathology, clinicalRecurrence

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
  • Understanding relapse patterns is crucial for improving patient outcomes.
  • Identifying early indicators of recurrence can aid in timely intervention.

Purpose of the Study:

  • To investigate the clinical and pathological characteristics differentiating relapsed DLBCL from complete response (CR) cases.
  • To identify predictors for early clinical screening of recurrent DLBCL.

Main Methods:

  • Retrospective analysis of 20 relapsed DLBCL patients and 34 DLBCL patients in CR for ≥36 months.
  • Comparison of clinical, laboratory, and pathological features between the two groups.
  • Statistical analysis to determine significant differences.

Main Results:

  • Relapsed DLBCL showed significant differences in Ann Arbor stage, International Prognostic Index (IPI) score, primary lesion site, extranodal involvement, HBV infection, and elevated LDH, CRP, and β2-MG levels.
  • Pathologically, relapsed cases were predominantly non-GCB type (85%) with higher CD5 positivity (25%) and lower bcl-6 positivity (60%) compared to CR cases.
  • No significant differences were observed in age, gender, ECOG score, B symptoms, hypoalbuminemia, anemia, or A/G ratio.

Conclusions:

  • Non-GCB type is the predominant subtype in relapsed DLBCL.
  • Clinical factors like CD5 positivity, advanced stage (III-IV), high IPI score (3-5), nodal origin, multiple extranodal sites, elevated LDH, CRP, β2-MG, and HBV infection are associated with a higher risk of relapse.