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Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants

Anna Materna-Kiryluk1, Katarzyna Wiśniewska2, Barbara Więckowska3

  • 1Polish Registry of Congenital Malformations, Chair and Department of Medical Genetics, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Children (Basel, Switzerland)
|September 30, 2020
PubMed

Insights

Infantile hemangiomas (IH) are linked to lower birth weight and gestational age. Female infants with a family history of IH show increased risk, suggesting multifactorial inheritance involving genetics and hormones.

Area of Science:

  • Pediatrics
  • Dermatology
  • Genetics

Background:

  • Infantile hemangiomas (IH) are common vascular tumors in infants.
  • Understanding IH predisposition is crucial for early intervention.
  • Etiology of IH is not fully understood, likely multifactorial.

Purpose of the Study:

  • Identify risk factors for infantile hemangiomas (IH).
  • Investigate predisposition to hemangioma development.
  • Analyze familial patterns and potential inheritance models.

Main Methods:

  • Retrospective analysis of live birth children with isolated cutaneous hemangioma.
  • Data collected from the Polish Registry of Congenital Malformations (1998-2016).
  • Statistical analysis to identify significant risk factors and familial associations.

Main Results:

  • Lower birth weight and gestational age are significant risk factors for IH.
  • Lower parental education showed a trend towards higher IH risk.
  • Female infants with maternal family history of IH had higher risk.

Conclusions:

  • Exogenous factors likely contribute to IH etiology.
  • Familial IH cases suggest a multifactorial inheritance model.
  • Female gender and hormonal influences may play a role in familial IH expression.

Keywords:
hereditary predispositioninfant hemangiomasrisk factorsvascular malformations

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