Chaperone Sigma1R and Antidepressant Effect
Mikhail V Voronin1, Yulia V Vakhitova1, Sergei B Seredenin1
1Department of Pharmacogenetics, FSBI "Zakusov Institute of Pharmacology", Baltiyskaya Street 8, 125315 Moscow, Russia.
Abstract:
This review analyzes the current scientific literature on the role of the Sigma1R chaperone in the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a result of ligand activation, Sigma1R is capable of intracellular translocation from the endoplasmic reticulum (ER) into the region of nuclear and cellular membranes, where it interacts with resident proteins. This unique property of Sigma1R provides regulation of various receptors, ion channels, enzymes, and transcriptional factors. The current review demonstrates the contribution of the Sigma1R chaperone to the regulation of molecular mechanisms involved in the antidepressant effect.
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