![Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F3777.jpg&w=3840&q=50)
Diagnostic Performance of 18F-FDG PET/CT in Native Valve Endocarditis: Systematic Review and Bivariate Meta-Analysis
Christel H Kamani1, Gilles Allenbach1, Mario Jreige1
1Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, CH-1011 Lausanne, Switzerland.
Diagnostics (Basel, Switzerland)
|September 30, 2020
Summary
Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) shows excellent specificity but poor sensitivity for diagnosing native valve endocarditis. Future research should explore methods to improve sensitivity without compromising accuracy.
Area of Science:
- Nuclear Medicine
- Radiology
- Infectious Diseases
Background:
- Infectious endocarditis is a serious condition requiring rapid diagnosis.
- Accurate diagnostic tools are crucial for effective treatment of native valve endocarditis (NVE).
Purpose of the Study:
- To systematically review and meta-analyze the diagnostic performance of 18F-FDG PET/CT for NVE.
- To estimate the sensitivity and specificity of 18F-FDG PET/CT in diagnosing NVE.
Main Methods:
- Comprehensive literature search of PubMed/MEDLINE and Cochrane databases until April 2020.
- Inclusion of studies evaluating the diagnostic accuracy of 18F-FDG PET/CT in suspected NVE cases.
- Systematic review and meta-analysis of seven included studies (351 NVE episodes).
Main Results:
- Pooled sensitivity for NVE diagnosis was 36.3%, while pooled specificity was 99.1%.
- Positive likelihood ratio was 8.3, negative likelihood ratio was 0.6, and diagnostic odds ratio was 15.3.
- Sensitivity may improve with advanced PET/CT technology, optimized patient preparation, and innovative imaging techniques.
Conclusions:
- 18F-FDG PET/CT demonstrates high specificity but low sensitivity for NVE diagnosis.
- Factors influencing sensitivity require further investigation in future studies.
- Optimizing imaging protocols may enhance the diagnostic utility of 18F-FDG PET/CT for NVE.
Keywords:
18F-FDGPET/CTdiagnostic performanceinfectious diseasesinfectious endocarditismeta-analysisnative valve endocarditispositron emission tomographysystematic review.More Related Videos
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