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[Clinical features of patients with hypertrophic obstructive cardiomyopathy combining obstructive sleep apnea]

J Wang1, H B Xu1, H P Zhang1

  • 1Coronary Heart Disease Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China.

Zhonghua Yi Xue Za Zhi
|September 30, 2020
PubMed

Insights

Over half of hypertrophic obstructive cardiomyopathy (HOCM) patients have obstructive sleep apnea (OSA). OSA severity correlates with cardiac remodeling and inflammation, suggesting monitoring sleep apnea improves HOCM patient outcomes.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Internal Medicine

Background:

  • Hypertrophic obstructive cardiomyopathy (HOCM) is a complex cardiac condition.
  • Obstructive sleep apnea (OSA) is a common sleep disorder with significant cardiovascular implications.
  • The co-occurrence of HOCM and OSA may influence disease progression and patient prognosis.

Purpose of the Study:

  • To investigate the clinical characteristics of patients with HOCM.
  • To determine the prevalence of OSA in HOCM patients.
  • To explore the relationship between OSA severity and cardiac remodeling in HOCM.

Main Methods:

  • Retrospective analysis of 299 HOCM patients undergoing sleep monitoring from 2010-2018.
  • Data collected included clinical features, echocardiography, and sleep breathing parameters.
  • OSA diagnosis was based on an apnea-hypopnea index (AHI) ≥ 5 events/hour.

Main Results:

  • OSA was diagnosed in 52.2% of HOCM patients.
  • OSA patients were older, had higher BMI, and a greater prevalence of hypertension, hyperlipidemia, and smoking history.
  • OSA was associated with increased NYHA functional class, atrial fibrillation, elevated blood pressure, glucose, hs-CRP, and larger left ventricular end-diastolic and ascending aorta diameters.
  • AHI positively correlated with left ventricular end-diastolic diameter, ascending aorta diameter, and hs-CRP levels.

Conclusions:

  • OSA is highly prevalent in HOCM patients.
  • OSA severity is linked to cardiac remodeling and elevated inflammatory markers.
  • Active monitoring and treatment of OSA in HOCM patients may improve clinical outcomes.

Keywords:
Cardiac remodelingHypertrophic obstructive cardiomyopathyObstructive sleep apnea

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