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Hyperuricemia prevalence in healthy subjects and its relationship with cardiovascular target organ damage

Alessandro Maloberti1, Esmerilda Qualliu2, Lucia Occhi1

  • 1Cardiology IV, "A. De Gasperis" Department, ASTT GOM Niguarda Ca' Granda, Milan, Italy; University of Milano-Bicocca, Milan, Italy.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|September 30, 2020
PubMed

Insights

High uric acid (hyperuricemia) is common in healthy adults. While linked to kidney function, high uric acid did not significantly predict cardiac or vascular damage in this study.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Metabolic Disorders

Background:

  • The relationship between uric acid (UA) and target organ damage (TOD) yields inconsistent findings.
  • Hyperuricemia prevalence and its association with TOD require further investigation in healthy populations.

Purpose of the Study:

  • To determine the prevalence of hyperuricemia in healthy individuals.
  • To assess the role of UA in predicting vascular, cardiac, and renal TOD.

Main Methods:

  • 379 healthy blood donors were analyzed.
  • Target organ damage assessed via Pulse Wave Velocity (PWV), Left Ventricular Mass Index (LVMI), and carotid Intima-Media Thickness (IMT).
  • Hyperuricemia defined by classic (>7.0 men/>6.0 women mg/dL) and recent (5.6 mg/dL for both sexes) cut-offs.

Main Results:

  • Hyperuricemia prevalence was 6.3% (classic cut-off) and 28.2% (recent cut-off).
  • UA significantly correlated with all TOD measures.
  • Multivariate regression revealed UA as a significant predictor only for Glomerular Filtration Rate (GFR), not other TODs, across genders.

Conclusions:

  • Hyperuricemia is prevalent in healthy subjects, with higher rates using lower cut-offs.
  • In this population, UA is significantly associated with renal impairment.
  • No significant association was found between UA and cardiac or vascular damage.
Abstract

Keywords:
Glomerular filtration rateHealthy subjectsPulse wave velocityTarget organ damageUric acid

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