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Severe hyperthermia due to oral baclofen withdrawal

Vishesh Paul1, Kari Righter2, Elise Kim2

  • 1Pulmonary & Critical Care Medicine, Carle Foundation Hospital, Urbana, Illinois, USA visheshpaul@gmail.com.

BMJ Case Reports
|September 30, 2020
PubMed

We report a case of a 53-year-old woman who presented initially with sepsis and later in her stay developed a severe and rapidly progressing hyperthermia after a decrease in oral baclofen dosage. Her fever peaked at 42.5○C (108.5○F), creating a broad differential diagnosis and complicating her initial sepsis diagnosis. When the oral baclofen dose was increased, the fevers resolved which confirmed the clinical diagnosis of baclofen withdrawal. Dose reductions of oral baclofen should be made gradually and with caution, and patients should be monitored for fevers as a possible symptom of baclofen withdrawal.

Keywords:
musculoskeletal and joint disordersunwanted effects / adverse reactions

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