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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
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Cigarette smoking patterns preceding primary Sjögren's syndrome
Johannes Mofors1, Albin Björk1, Elina Richardsdotter Andersson1
1Division of Rheumatology, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
RMD Open
|September 30, 2020
Summary
Individuals who develop primary Sjögren's syndrome (pSS) smoke similarly to the general population in early life but are more likely to quit later. This suggests smoking may have a protective effect or early pSS symptoms influence smoking habits.
Area of Science:
- Rheumatology
- Immunology
- Epidemiology
Background:
- Cigarette smoking is a known risk factor for various autoimmune diseases.
- The specific association between smoking and primary Sjögren's syndrome (pSS) requires further investigation.
Purpose of the Study:
- To investigate the relationship between cigarette smoking and the subsequent development of primary Sjögren's syndrome (pSS).
Main Methods:
- A case-control study involving 815 patients with pSS and 4425 matched controls.
- Smoking habits were assessed using lifestyle questionnaires.
- Conditional logistic regression and multivariate regression were used for analysis, including interactions with human leucocyte antigens (HLA).
Main Results:
- Ever smoking before diagnosis was lower in pSS patients (OR 0.67).
- Current smoking at diagnosis was also less prevalent (OR 0.37).
- Patients with pSS showed a higher tendency to quit smoking years before diagnosis (OR 2.01), with no significant interaction between smoking and HLA-DRB1 haplotypes.
Conclusions:
- Individuals developing pSS smoke similarly to controls in early life but quit more readily.
- This pattern may suggest a protective effect of smoking or reflect early, subtle pSS symptoms influencing smoking behavior.
- The findings highlight the potential for slow, progressive disease development in pSS.
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