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Updated: Dec 7, 2025

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
Published on: February 27, 2018
Huntington's disease-like 2: a phenocopy not to miss
Daniel Sabino De Oliveira1, Daniela Pereira Santos1, Daniel Oliveira Araujo1
1Neurology Service, University Hospital, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
Abstract:
A 67-year-old Brazilian man of African ancestry and his 60-year-old sister both presented with choreiform movements, although in the man these were significantly overshadowed by additional parkinsonism. The man also had a history of four epileptic seizures. Neurological examination in each also found slow saccades and a dysexecutive syndrome. Genetic tests for Huntington's disease were negative but were positive for Huntington's disease-like 2. There are various genetic causes of chorea diseases, and their correct identification is important for appropriate clinical management and genetic counselling.
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