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Published on: January 5, 2017
Controlled drug release for inflammatory bowel disease (IBD)
D Asha1, S Jeganath2, G Bupesh3,4
1Department of Microbiology, Saastra College of Pharmaceutical Education and Research, Nellore, AP, India.
Abstract:
Controlled drug release in formulation is an important area of research. Formulations using crospovidone as super-disintegrants to achieve immediate release once it reaches the ileo- cecal region is relevant. The Eudragit L30D pH dependent polymer that allows drug release after a lag time of 4-5 hrs to achieve desired drug release from the drug delivery system is critical. Hence, pre-formulation to study drug-polymer interaction is essential. The linear correlation between the predicted and actual values for all the batches of optimization is shown with high correlation coefficient (r-value). Therefore, the designed formulation is promising for ileo-cecal targeted pulsatile drug delivery system in the management of Crohn's disease.
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