Acute Toxicity Related to 25G-NBOMe Use: An Internet High

The NBOMe series is an emerging class of synthetic hallucinogens with limited data available on their use and effects. Whilst toxicity to related substances exist in the literature, no such cases exist for 25G-NBOMe. This case describes a 17-year old male who presented to the Emergency Department with seizures having ingested 25G-NBOMe that had been purchased over the Internet. He was tachycardic, hypotensive and hyperthermic on arrival and required admission to the Intensive Care Unit (ICU) due a persistently low Glasgow Coma Scale (GCS) and profound metabolic derangement. His inpatient stay was prolonged by a persistently high creatine kinase with associated transient acute kidney injury. In contrast, an accompanying friend who had ingested the same drug developed no adverse effects. Our patient's clinical presentation was consistent with reports of adverse outcomes associated with other drugs in the series and demonstrates that acute toxicity can also be seen with 25G-NBOMe with potentially life threatening outcomes.