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Methylprednisolone pulse therapy: An alternative management of severe COVID-19

Patricia Merab Sauñe1, Mayte Bryce-Alberti2, Arianna Sibila Portmann-Baracco2

  • 1Facultad de Medicina, Universidad Privada San Juan Bautista, José Antonio Ave, 302-304, Chorrillos District, Lima, Peru.

Respiratory Medicine Case Reports
|September 30, 2020
PubMed

Insights

Severe COVID-19 cases managed at home with methylprednisolone (MP) pulse therapy showed favorable outcomes. This treatment effectively resolved symptoms, highlighting MP

Area of Science:

  • Infectious Diseases
  • Immunology
  • Pharmacology

Background:

  • COVID-19 presents with varying severity, from asymptomatic to severe respiratory disease.
  • Severe COVID-19 progression is linked to a "cytokine storm," an excessive inflammatory response.
  • Glucocorticoids (GC) modulate inflammation; high-dose pulse therapy can induce immune cell apoptosis.

Observation:

  • Two severe COVID-19 cases, initially denied medical care, were managed at home.
  • Treatment involved three-day methylprednisolone (MP) pulse therapy.
  • Patients experienced favorable symptom evolution and resolution.

Findings:

  • Home-based methylprednisolone pulse therapy demonstrated efficacy in severe COVID-19.
  • This approach led to significant clinical improvement and symptom resolution.
  • Findings suggest MP pulse therapy can mitigate the inflammatory cascade in severe COVID-19.

Implications:

  • Timely GC administration, particularly MP pulse therapy, may prevent Acute Respiratory Distress Syndrome (ARDS).
  • This treatment strategy offers a potential alternative for managing severe COVID-19, especially when institutional care is limited.
  • Further research into GC pulse therapy for COVID-19-induced cytokine storms is warranted.
Keywords:
COVID-19Cytokine stormMethylprednisolonePulse therapyTreatment

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