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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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Related Experiment Video

Updated: Dec 7, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence.

Kanglin Hsieh, Yinyin Wang, Luyao Chen

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    This study prioritized existing drugs for COVID-19 treatment using a novel pipeline integrating biological interactions and deep learning. It identified 22 promising candidate drugs, including Azithromycin and Aspirin, for potential SARS-CoV-2 therapies.

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    Area of Science:

    • * Computational biology and bioinformatics
    • * Drug discovery and pharmacology
    • * Infectious disease research

    Background:

    • * The COVID-19 pandemic caused by SARS-CoV-2 has seen extensive but largely unsuccessful drug research efforts.
    • * Repurposing existing drugs offers a faster route to potential treatments.

    Conclusions:

    • * The integrated drug repurposing pipeline effectively identifies promising candidates for COVID-19.
    • * Combining deep learning with rigorous validation accelerates the discovery of potential SARS-CoV-2 therapeutics.
    • * This strategy facilitates the rapid development of urgently needed treatments for infectious diseases.